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백서에 전신적으로 투여한 Formocresol과 Glutaraldehyde의 독성에 관한 연구
ACUTE TOXICITY OF SYSTEMICALLY ADMINISTERED FORMOCRESOL AND GLUTARALDEHYDE IN BATS

대한소아치과학회지 1990년 17권 1호 p.211 ~ 222

김용남, 윤영수,

소속 상세정보

김용남 ( ) - 전북대학교 의과대학 외과학교실
윤영수 ( ) - 전남대학교 치과대학 소아치과학교실

KMID : 0358919900170010211

Abstract

결론
저자는 전신적으로 흡수된 formocresol과 glutaraldehyde의 급성독성을 구명하기 위해,
Buckley's tormocresol과 2% buffered glutaraldehyde를 백서의 결정맥내로 각각 0.15ml/kg
를 투여하여 다음과 같은 결과를 얻었다.
1. Formocresol과 glutaraldehyde를 투여한 후 혈압 및 심박수가 유의하게 감소하였다.
2. 혈액의 화학적 검사상, formocresol군에서는 AST 및 ALT치, glutaraldehyde군에서는
AST 치가 대조군에 비해 유의하게 높았다.
3. Formocresol과 glutaraldehyde 투여후 신기능의 변화는 관찰되지 않았다.
4. 조직학적 검사상 formocresol 및 glutaraldehyde 군 모두에서 특이한 소견이 관찰되지
않았다.
이상의 결과로 formocresol은 전신독성, 특히 간조직에 대한 독성 이 큰 것으로 사료되며,
glutaraldehyde도 전신 독성을 가지나 formocresol보다 낮음을 시사하였다.
#초록#
Formocresol and glutaraldehyde applied to the remaining radicular pulp may be
absorbed systemically during the vital pulpotomy.
The present study was performed to investigate the acute toxicity of formocresol and
glutaraldehyde when administered intravenously in rats. The animals were divided into 3
groups. The thirst control group received physiologic saline, the second Buckley's
formocresol and the third 2% buffered glutaraldehyde solution intravenously at a dose of
0.15m1/kg respectively. Blood pressure and heart rate recordings and timed urine
collections were made for 3 hours after injection of the drugs. Blood samples were
taken for chemical analyses and the tissue samples of liver, kidney, heart and lung were
collected for histological evaluation after 6 hours.
The following results were obtained ;
1. Blood pressure and heart rate were significantly decreased following administration
of formocresol or glutaraldehyde.
2. S-AST and S-ALT values of the formooesol group were significantly higher than
those of the control group. In the glutaraldehyde group, S-AST value was higher than
that of the control group.
3. No significant changes were observed in renal function following administration of
formocresol or glutaraldehyde.
4. Tissue injury was not evident histologically 6 hours after administration of the drug.
These results indicate that formocresol and glutaraldehyde may cause a systemic toxic
effect, especially on the hepatic tissue, and that formocresol may be more toxic than
glutaraldehyde.